1H-Indazol-6-amine → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(1H-indazol-6-yl)-pyrimdine-2,4-diamine

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Reaction Steps

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 1H-indazol-6-ylamine provided the title compound (65% yield). 1H NMR (DMSO-d6) δ 1.34 (t, 3H, J=6.9 Hz, CH3), 4.13 (q, 2H, J=6.9 Hz, CH2), 6.26 (s, 2H, NH2), 6.85 (s, 1H, Ar), 7.14 (d, 1H, J=8.9 Hz, Ar), 7.30 (d, 1H, J=8.6 Hz, Ar), 7.41 (dd, 1H, J-8.9 Hz, 2.7 Hz, Ar), 7.65 (d, 1H, J=8.9 Hz, Ar), 7.95-7.97 (m, 3H, Ar), 9.27 (s, 1H, NH), 12.80 (s, 1H, NH).

Provenance & Evidence