4-Chloroaniline → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

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Reaction Steps

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-chloro-phenylamine provided the title compound (45% yield). 1H NMR (DMSO-d6) δ 1.39 (t, 3H, J=6.9 Hz, CH3), 4.14 (q, 2H, J=6.5 Hz, CH2), 6.36 (s, 2H, NH2), 6.78 (s, 1H, Ar), 7.15 (d, 1H, J=8.9 Hz, Ar), 7.32 (d, 2H, J=8.9 Hz, Ar), 7.41 (dd, 1H, J=8.8, 2.8 Hz, Ar), 7.79 (d, 2H, J=8.9 Hz, Ar), 7.91 (d, 1H, J=2.8 Hz), 9.31 (s, 1H, NH).

Provenance & Evidence