HRID28585

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(CO)cc2)nc(N)n1

HCID10406874

未命名化合物

结构：CC(C)(C)OC(=O)NC(CC(=O)O)C(=O)OC(C)(C)C

HCID14037600

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc(Cl)cc1-c1cc(Nc2ccc(COC(=O)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc2)nc(N)n1

HCID68987504

未命名化合物

PROCEDURE

实验过程

(S)-2-tert-Butoxycarbonylamino-succinic acid 4-{4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl} ester 1-tert-butyl ester was prepared according to the method described for Example 64 by using the title compound of Example 44 and 2-tert-butoxycarbonylamino-succinic acid 1-tert-butyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bce7816e630149e4bcb49cdef77b2972
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07419984B2
来源说明: uspto-grants-2008_09

反应 SMILES

[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][OH:16])=[CH:11][CH:10]=2)[CH:5]=[C:4]([C:17]2[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:18]=2[O:24][CH2:25][CH3:26])[N:3]=1.[C:27]([O:31][C:32](=[O:46])[CH:33]([NH:38][C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:34][C:35](O)=[O:36])([CH3:30])([CH3:29])[CH3:28]>>[C:27]([O:31][C:32](=[O:46])[C@@H:33]([NH:38][C:39]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[O:40])[CH2:34][C:35]([O:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([NH:8][C:6]2[CH:5]=[C:4]([C:17]3[CH:22]=[C:21]([Cl:23])[CH:20]=[CH:19][C:18]=3[O:24][CH2:25][CH3:26])[N:3]=[C:2]([NH2:1])[N:7]=2)=[CH:10][CH:11]=1)=[O:36])([CH3:30])([CH3:29])[CH3:28]