Hydrochloric Acid → (S)-2-Amino-succinic acid 4-{4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl}ester

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Reaction Steps

Following the method described in Example 64, (S)-2-tert-butoxycarbonylamino-succinic acid 4-{4-[2-amino-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-4-ylamino]-benzyl} ester 1-tert-butyl ester and hydrogen chloride provided the title compound (69% yield). 1H NMR (DMSO-d6) δ 1.39 (t, 3H, J=7.0 Hz, CH3), 3.00-3.03 (m, 2H, CH2), 4.17 (q, 2H, J=6.9 Hz, CH2), 4.24 (s, 1H, CH), 5.16 (s, 2H, CH2), 6.74 (s, 1H, Ar), 7.28 (d, 1H, J=8.9 Hz, Ar), 7.43 (d, 2H, J=8.4 Hz, Ar), 7.61-7.68 (m, 2H, Ar), 7.88 (d, 2H, J=8.0 Hz, Ar), 8.52 (s, 3H), 11.23 (s, 1H), 12.77 (s, 1H).

Provenance & Evidence