反应详情

A mixture of the title compound of Example 29 (0.19 g, 0.50 mmol) and succinic anhydride (0.30 g, 3.0 mmol) in toluene (18 ml) was heated under reflux for 6 hours. After cooled to room temperature, the mixture was filtered. The filtrate was washed with saturated aqueous sodium bicarbonate solution (3×10 ml), dried over magnesium sulfate, and concentrated under reduced pressure to provide 1-[4-(5-chloro-2-methyl-phenyl)-6-(4-trifluoromethyl-phenylamino)-pyrimidin-2-yl]-pyrrolidine-2,5-dione as a white solid (96% yield).

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. filtrationthe mixture was filtered
4. washThe filtrate was washed with saturated aqueous sodium bicarbonate solution (3×10 ml)
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure