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HRID2861

反应详情

EQUATION

反应方程式

HRID 2861 的结构方程式

REACTANTS

反应物

2
结构：BrB(Br)Br
HCID25134

Boron tribromide

BBr3

结构：CCOC(=O)c1[nH]c2c(c1C)C[C@@H]1CN(CC)CC[C@@]1(c1cccc(OC)c1)C2
HCID22883674

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1[nH]c2c(c1C)C[C@@H]1CN(CC)CC[C@@]1(c1cccc(O)c1)C2
HCID22883675

未命名化合物

收率 20.9%

PROCEDURE

实验过程

0.6 g (1.5 mmol) of (±)-trans-6-ethyl-2-ethoxycarbonyl-3-methyl-8a-(3-methoxyphenyl)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline were treated with 0.84 ml (9.0 mmol) of boron tribromide as described in example 2. The crude solid was purified by flash chromatography (AcOEt/MeOH/conc. NH4OH 80:20:2), yielding 0.12 g of the title compound. M.p.=195°-197° C.

WORKUP

后处理

  1. customThe crude solid was purified by flash chromatography (AcOEt/MeOH/conc. NH4OH 80:20:2)