4-Bromoaniline → HCID 11295314, compound

Participants

Reaction Steps

Following the method described in Example 26, 4-[5-bromo-2-(2,2,2-trifluoro-ethoxy)-phenyl]-6-chloro-pyrimidin-2-ylamine and 4-bromo-phenylamine provided the title compound (34% yield). 1H NMR (acetone-d6) δ 4.76 (q, 2H, J=8.5 Hz, CH2), 5.95 (bs, 2H, NH2), 6.72 (s, 1H, Ar), 7.21 (d, 1H, J=8.8 Hz, Ar), 7.44 (d, 2H, J=8.9 Hz, Ar), 7.58 (dd, 1H, J=8.8 Hz, J=2.4 Hz, Ar), 7.75-7.78 (m, 2H, Ar), 8.07 (d, 1H, J=2.4 Hz, Ar), 8.62 (br s, 1H, NH).

Provenance & Evidence