Bicarbonate Ion → Methyl 1-(4-(3-amino-6-bromoquinolin-4-ylamino)-2-(trifluoromethyl)phenyl)piperidine-4-carboxylate
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([NH:15][c:16]3[cH:17][c:18]([C:32]([F:33])([F:34])[F:35])[c:19]([N:22]4[CH2:23][CH2:24][CH:25]([C:28](=[O:29])[O:30][CH3:31])[CH2:26][CH2:27]4)[cH:20][cH:21]3)[c:6]([N+:12]([O-:13])=[O:14])[cH:7][n:8][c:9]2[cH:10][cH:11]1.[Na+:45].[O-:41][C:42]([OH:43])=[O:44].[O:46]1[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1.[OH2:36].[OH2:37].[Sn:38]([Cl:39])[Cl:40]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([NH:15][c:16]3[cH:17][c:18]([C:32]([F:33])([F:34])[F:35])[c:19]([N:22]4[CH2:23][CH2:24][CH:25]([C:28](=[O:29])[O:30][CH3:31])[CH2:26][CH2:27]4)[cH:20][cH:21]3)[c:6]([NH2:12])[cH:7][n:8][c:9]2[cH:10][cH:11]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-92fe5cb746f64d629633fcd5128c9211
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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