4-Chloroaniline → N*4*-(4-Chloro-phenyl)-6-phenyl-pyrimidine-2,4-diamine

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Reaction Steps

Following the method described in Example 53, 4-chloro-6-phenyl-pyrimidin-2-ylamine and 4-chloro-phenylamine provided the title compound as the hydrochloride salt (63% yield). 1H NMR (DMSO-d6) δ 6.70 (s, 1H, Ar), 7.47 (d, 2H, J=8.7 Hz, Ar), 7.66 (d, 3H, J=6.9 Hz, Ar), 7.88 (d, 4H, J=7.2 Hz, Ar), 9.42 (s, 1H, NH), 12.91 (s, 1H, NH).

Provenance & Evidence