HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroaniline → 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(2-chloro-phenyl)-pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroaniline | HCID 7240 | — |
| Reactant | 4-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine | HCID 86004325 | — |
| Product | 6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(2-chloro-phenyl)-pyrimidine-2,4-diamine | HCID 44314131 | 31% |
Reaction Steps
Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 2-chloroaniline provided the title compound (31% yield). 1H NMR (DMSO-d6) δ 1.19-1.22 (t, 3H, CH3), 4.0-4.1 (q, 2H, CH2), 6.0-6.30 (s, 2H, NH2), 6.65 (s, 1H, Ar), 7.05-7.29 (m, 4H, Ar), 7.316 (d, 1H, Ar) 7.354 (d, 1H, Ar) 7.90 (d, 1H, Ar) 8.8 (br s, 1H, NH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419984B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-473731f08edb4fc6bd00d07111c1c57f |
| Source note | uspto-grants-2008_09 |