2-Amino-4,6-dichloropyrimidine → HCID 87645982, compound

HRID 28623Notes

Reaction equation

HRID 28623 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:9]=2OCC)[N:5]=[C:4]([NH2:18])[N:3]=1.[Cl:19]C1C(Cl)=CC=CC=1B(O)O.NC1N=C(Cl)C=C(Cl)N=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([Cl:14])[C:13]=2[Cl:19])[N:5]=[C:4]([NH2:18])[N:3]=1

Participants

4

Reactant 3

HCID 655222-Amino-4,6-dichloropyrimidineHCID 27346612,3-Dichlorobenzeneboronic acidHCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

Product 1

HCID 87645982HCID 87645982, compound

Procedure

4-Chloro-6-(2,3-dichloro-phenyl)-pyrimidin-2-ylamine was prepared according to the method described for 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine (Example 53) using 2,3-dichlorophenyl boronic acid and 2-amino-4,6-dichloropyrimidine.

Sources & evidence

ORD record
ord-259a30fc5e5e4324970d143e2ce02bf7
Source dataset
uspto-grants-2008_09
Patent number
US07419984B2

Reaction notes

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