2-Amino-4,6-dichloropyrimidine → 2-Pyrimidinamine,4-(3-bromophenyl)-6-chloro-

HRID 28625Notes

Reaction equation

HRID 28625 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[C:12](Cl)[CH:11]=[CH:10][C:9]=2OCC)[N:5]=[C:4]([NH2:18])[N:3]=1.[Br:19]C1C=C(B(O)O)C=CC=1.NC1N=C(Cl)C=C(Cl)N=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:9]=[CH:10][CH:11]=[C:12]([Br:19])[CH:13]=2)[N:5]=[C:4]([NH2:18])[N:3]=1

Participants

4

Reactant 3

HCID 655222-Amino-4,6-dichloropyrimidineHCID 2734318(3-Bromophenyl)boronic acidHCID 860043254-Chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

Product 1

HCID 587333892-Pyrimidinamine,4-(3-bromophenyl)-6-chloro-

Procedure

4-Chloro-6-(3-bromo-phenyl)-pyrimidin-2-ylamine was prepared according to the method described for 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine (Example 53) using 3-bromophenyl boronic acid and 2-amino-4,6-dichloropyrimidine.

Sources & evidence

ORD record
ord-0dbb5c3a2fc24532802ca8f58207034a
Source dataset
uspto-grants-2008_09
Patent number
US07419984B2

Reaction notes

Loading…