HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → 6-(3-Bromo-phenyl)-N*4*-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | 2-Pyrimidinamine,4-(3-bromophenyl)-6-chloro- | HCID 58733389 | — |
| Product | 6-(3-Bromo-phenyl)-N*4*-(4-trifluoromethyl-phenyl)-pyrimidine-2,4-diamine | HCID 59788264 | 30% |
Reaction Steps
Following the method described in Example 53, 4-chloro-6-(3-bromo-phenyl)-pyrimidin-2-ylamine and 4-trifluoromethylaniline provided the title compound (30% yield). 1H NMR (CD3OD) δ 6.50 (s, 1H, Ar), 7.25-7.35 (t, 1H, Ar), 7.4-7.6 (m, 4H, Ar) 7.88 (d, 1H, Ar), 7.90 (d, 1H, Ar) 7.96 (d, 2H, Ar), 8.10 (s, 1H, Ar).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419984B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-23d96adfa30148e890ed5a7faaf56e6e |
| Source note | uspto-grants-2008_09 |