HRID2863

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25134

Boron tribromide

BBr3

结构：CCN1CC[C@@]2(c3cccc(OC)c3)Cc3[nH]c(C(=O)OCC(C)C)c(C)c3C[C@@H]2C1.Cl

HCID22883663

未命名化合物

PRODUCTS

生成物

结构：CCN1CC[C@@]2(c3cccc(O)c3)Cc3[nH]c(C(=O)OCC(C)C)c(C)c3C[C@@H]2C1.Cl

HCID22883665

未命名化合物

PROCEDURE

实验过程

0.56 g of (±)-trans-2-(i-butoxycarbonyl)-6-ethyl-3-methyl-8a-(3-methoxyphenyl)-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline hydrochloride were treated with 0.68 ml (7.26 mmol) of boron tribromide as described in example 2. The residue was purified by flash chromatography (AcOEt/MeOH/conc. NH4OH 75:25:2.5) and then crystallised from AcOEt yielding 0.1 g of the title compound. M.p.=196°-198° C.

WORKUP

后处理

customThe residue was purified by flash chromatography (AcOEt/MeOH/conc. NH4OH 75:25:2.5)
customcrystallised from AcOEt yielding 0.1 g of the title compound