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2-Amino-4,6-dichloropyrimidine → 4-(5-Bromo-2-methoxyphenyl)-6-chloropyrimidin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| 反応物 | 5-Bromo-2-methoxyphenylboronic acid | HCID 4532730 | — |
| 反応物 | 4-Chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine | HCID 86004313 | — |
| 生成物 | 4-(5-Bromo-2-methoxyphenyl)-6-chloropyrimidin-2-amine | HCID 59104310 | 53% |
反応手順
Following the method described in Example 4 for the synthesis of 4-chloro-6-(5-chloro-2-methoxy-phenyl)-pyrimidin-2-yl-amine, 4,6-dichloro-pyrimidin-2-yl-amine and 5-bromo-2-methoxy-phenyl boronic acid provided 4-chloro-6-(5-bromo-2-methoxy-phenyl)-pyrimidin-2-yl-amine (53% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07419984B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-eea57b5abc9e4e88b86d78be715ab55b |
| 出典メモ | uspto-grants-2008_09 |