HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Dimethylamino)-1-propanol → 4-[5-Bromo-2-(3-dimethylamino-propoxy)-phenyl]-6-chloro-pyrimidin-2-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Dimethylamino)-1-propanol | HCID 76646 | — |
| Reactant | 4-(5-Bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine | HCID 86004374 | — |
| Reactant | 2-(2-Amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol | HCID 136080012 | — |
| Product | 4-[5-Bromo-2-(3-dimethylamino-propoxy)-phenyl]-6-chloro-pyrimidin-2-ylamine | HCID 86594605 | 43% |
Reaction Steps
Following the method described in Example 135 for the synthesis of 4-(5-bromo-2-propoxy-phenyl)-6-chloro-pyrimidin-2-ylamine, 2-(2-amino-6-chloro-pyrimidin-4-yl)-4-bromo-phenol and 3-dimethylamino-propan-1-ol provided 4-[5-bromo-2-(3-dimethylamino-propoxy)-phenyl]-6-chloro-pyrimidin-2-ylamine (43% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07419984B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-7a5325ec5da74e54b5ce889c69aecb6e |
| Source note | uspto-grants-2008_09 |