4-Chloroaniline → 6-(5-Chloro-2-cyclohexylmethoxy-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

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Reaction Steps

Following the method described in Example 72, 4-chloro-6-(5-chloro-2-cyclohexylmethoxy-phenyl)-pyrimidin-2-yl-amine and 4-chloro-aniline provided the title compound (98% yield). 1H NMR (DMSO-d6) δ 1.15-1.19 (m, 4H, CH2) δ 1.65-1.73 (m, 6H, CH2), 3.89 (d, 2H, J=5.7 Hz, Ar), 6.49 (s, 1H, Ar), 7.27 (d, 1H, J=8.4 Hz, Ar), 7.46 (d, 2H, J=8.7 Hz, Ar), 7.61 (d, 2H, J=8.5 Hz, Ar), 7.82-7.85 (m, 2H, Ar).

Provenance & Evidence