Allyl bromide → 6-(2-Allyloxy-5-chloro-phenyl)-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

Participants

Reaction Steps

Following the method described in Example 165, 2-[2-amino-6-(4-chloro-phenylamino)-pyrimidin-4-yl]-4-chloro-phenol and 3-bromo-propene provided the title compound (80% yield) 1H NMR (DMSO-d6) δ 4.68 (d, 2H, CH2), 5.25-5.28 (m, 1H, Ar), 5.36-5.41 (m, 1H, Ar), 6.03-6.08 (m, 1H, Ar), 6.36 (s, 2H, NH2), 6.70 (s, 1H, Ar), 7.14 (d, 1H, J=8.9 Hz, Ar), 7.31 (d, 2H, J=8.9 Hz, Ar), 7.40 (dd, 1H, J—2.8 Hz, J=8.8 Hz, Ar), 7.78 (d, 2H, J=8.9 Hz, Ar), 7.85 (d, 1H, J=2.8 Hz, Ar), 9.32 (s, 1H, NH).

Provenance & Evidence