4-Chloroaniline → 6-[5-Bromo-2-(2-methoxy-benzyloxy)-phenyl]-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

Beteiligte Stoffe

Reaktionsschritte

Following the method described in Example 178, 6-[5-bromo-2-(2-methoxy-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine and 4-chloro-phenylamine provided the title compound (57% yield). 1H NMR (CD3OD) δ 3.82 (s, 3H, CH3), 5.25 (s, 2H, CH2), 6.35 (s, 1H, Ar), 6.89-6.98 (m, 2H, Ar), 7.21-7.48 (m, 3H, Ar), 7.38-7.42 (m, 2H, Ar), 7.69-7.82 (m, 4H, Ar).

Herkunft & Nachweise