2,2-Difluoroethyl trifluoromethanesulfonate → 4-[1-(2,2-Difluoro-ethyl)-5-(1-isopropyl-piperidin-4-yloxy)-1H-indole-2-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:15])[c:16]2[nH:17][c:18]3[cH:19][cH:20][c:21]([O:25][CH:26]4[CH2:27][CH2:28][N:29]([CH:32]([CH3:33])[CH3:34])[CH2:30][CH2:31]4)[cH:22][c:23]3[cH:24]2)[CH2:12][CH2:13]1.[F:35][C:36]([F:37])([F:38])[S:39]([O:40][CH2:41][CH:42]([F:43])[F:44])(=[O:45])=[O:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:15])[c:16]2[n:17]([CH2:41][CH:42]([F:43])[F:44])[c:18]3[cH:19][cH:20][c:21]([O:25][CH:26]4[CH2:27][CH2:28][N:29]([CH:32]([CH3:33])[CH3:34])[CH2:30][CH2:31]4)[cH:22][c:23]3[cH:24]2)[CH2:12][CH2:13]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-4200e37ac46244c38d19f457c4002ec6
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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