HRID2870

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25134

Boron tribromide

BBr3

结构：CCN1CC[C@@]2(c3cccc(OC)c3)Cc3[nH]c(C(=O)Nc4ccccc4)c(C)c3C[C@@H]2C1

HCID22883679

未命名化合物

PRODUCTS

生成物

结构：CCN1CC[C@@]2(c3cccc(O)c3)Cc3[nH]c(C(=O)Nc4ccccc4)c(C)c3C[C@@H]2C1

HCID22883680

未命名化合物

收率 22.1%

PROCEDURE

实验过程

0.28 g of (±)-trans-6-ethyl-8a-(3-methoxyphenyl)-3-methyl-2-phenylaminocarbonyl-4,4a,5,6,7,8,8a,9-octahydro-1H-pyrrolo[2,3-g]isoquinoline were treated with 0.35 (1.9 mmol) of boron tribromide as described in example 2. The residue was purified by flash chromatography (EtOAc/MeOH/conc. NH4OH 80:20:2) yielding 0.06 g of the title compound. M.p.=271°-272° C.

WORKUP

后处理

customThe residue was purified by flash chromatography (EtOAc/MeOH/conc. NH4OH 80:20:2)