6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine → HCID 178521856, compound

HRID 28713Notes

Reaction equation

HRID 28713 reaction equation
[NH:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[N:2]1.[Cl:9][C:10]1[CH:11]=[C:12]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18]1[CH:17]([NH2:23])[CH2:16][CH2:15][CH2:14][C:13]2=1>>[Cl:9][C:10]1[CH:11]=[C:12]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18]1[CH:17]([NH:23][C:6]([C:3]3[CH:4]=[CH:5][NH:1][N:2]=3)=[O:8])[CH2:16][CH2:15][CH2:14][C:13]2=1

Participants

3

Reactant 2

HCID 177434976-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amineHCID 178524567HCID 178524567, compound

Product 1

HCID 178521856HCID 178521856, compound

Procedure

N-(6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl)-1H-pyrazole-3-carboxamide was prepared from 1H-pyrazole-3-carboxylic acid and 6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-amine in a similar manner as described above to give a white solid (16% yield). 1H-NMR (CD3OD-d4): δ 7.70 (d, 1H), 7.37 (d, 1H), 7.22 (d, 1H), 6.99 (dd, 1H), 6.81 (d, 1H), 5.37 (m, 1H), 2.70 (m, 2H), 2.19 (m, 1H), 2.00 (m, 3H); MS m/z 313 (M−1).

Sources & evidence

ORD record
ord-d7faeff98f9d4f33aa65dd37e6615162
Source dataset
uspto-grants-2008_09
Patent number
US07419997B2

Reaction notes

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