Methanol → Tert-butyl 3-[(3-chloro-2-fluorophenyl)-hydroxymethyl]piperidine-1-carboxylate
Reaction equation
[BH4-:24].[CH3:26][OH:27].[Cl:1][c:2]1[c:3]([F:23])[c:4]([C:5](=[O:6])[CH:7]2[CH2:8][N:9]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:10][CH2:11][CH2:12]2)[cH:20][cH:21][cH:22]1.[Na+:25]>>[Cl:1][c:2]1[c:3]([F:23])[c:4]([CH:5]([OH:6])[CH:7]2[CH2:8][N:9]([C:13](=[O:14])[O:15][C:16]([CH3:17])([CH3:18])[CH3:19])[CH2:10][CH2:11][CH2:12]2)[cH:20][cH:21][cH:22]1Participants
5
Sources & evidence
- ORD record
- ord-8b4b77d9f8464bc4abe1965cf6be6af1
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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