Methyl 4-methoxyacetoacetate → 2-[3-Chloro-4-({[4-methoxymethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine-5-carbonyl]-amino}-methyl)-phenoxy]-2-methyl-propionic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][c:11]([Cl:17])[c:12]([CH2:15][NH2:16])[cH:13][cH:14]1)=[O:18].[CH2:29]([CH2:30][C:31]([Br:32])([CH3:33])[C:34]([O-:35])=[O:36])[CH3:37].[CH3:38][O:39][CH2:40][c:41]1[n:42][c:43](-[c:50]2[cH:51][cH:52][c:53]([C:56]([F:57])([F:58])[F:59])[cH:54][cH:55]2)[n:44][cH:45][c:46]1[C:47](=[O:48])[OH:49].[CH3:60][O:61][C:62](=[O:63])[CH2:64][C:65](=[O:66])[CH2:67][O:68][CH3:69].[Cl:19][c:20]1[cH:21][c:22]([OH:23])[cH:24][cH:25][c:26]1[CH:27]=[O:28]>>[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][c:11]([Cl:17])[c:12]([CH2:15][NH:16][C:47]([c:46]2[c:41]([CH2:40][O:39][CH3:38])[n:42][c:43](-[c:50]3[cH:51][cH:52][c:53]([C:56]([F:57])([F:58])[F:59])[cH:54][cH:55]3)[n:44][cH:45]2)=[O:48])[cH:13][cH:14]1)=[O:18]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-3be45b1c93f945c8bcf4326c5fe222b2
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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