反应详情

To a solution of methyl 1-(3-fluorophenyl)cyclopentanecarboxylic acid (5.0 g, 24.01 mmol) in anhydrous methanol was added 1 mL of concentrated sulfuric acid. The mixture was refluxed overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL, dried over MgSO4. The crude product was used for the next reaction without further purification.

1. temperatureThe mixture was refluxed overnight
2. customThe solvent was evaporated
3. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
4. washwashed with brine (3×10 mL
5. dry with materialdried over MgSO4
6. customThe crude product was used for the next reaction without further purification