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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 287734Generated: October 25, 2026

Methanol → 8-(1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-3-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

https://huagongshe.com/reaction/287734

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
Reactant1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1H-pyrazol-3-ylamineHCID 59344947—
Reactant6,8-Dichloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamideHCID 59624549—
Reactant6-chloro-N-(3-fluoropyridin-4-yl)-8-(1-isopropyl-1H-pyrazol-3-ylamino)imidazo[1,2-b]pyridazine-3-carboxamideHCID 86649269—
Product8-(1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-3-ylamino)-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamideHCID 86649270—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (8/10)
ORD IDord-8a6d8dacd4af4037a1112977732767f2
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (8/10)