反应详情

To a solution of methyl 1-(2-fluorophenyl)cyclopentanecarboxylic acid (10 g, 52.56 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

1. temperatureThe mixture was refluxed for overnight
2. customThe solvent was evaporated
3. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
4. washwashed with brine (3×10 mL)
5. dry with materialdried over MgSO4
6. customThe crude product was used for the next reaction without further purification