4-bromo-3-(4H-1,2,4-triazol-3-yl)thiophen-2-amine → N-(4-Bromo-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl)-2-(8-fluoroisoquinolin-5-yl)acetamide
Reaction equation
[Br:16][c:17]1[c:18](-[c:23]2[n:24][cH:25][n:26][nH:27]2)[c:19]([NH2:22])[s:20][cH:21]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:12][C:13](=[O:14])[OH:15])[c:6]2[cH:7][cH:8][n:9][cH:10][c:11]12>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:12][C:13](=[O:15])[NH:22][c:19]2[c:18](-[c:23]3[n:24][cH:25][n:26][nH:27]3)[c:17]([Br:16])[cH:21][s:20]2)[c:6]2[cH:7][cH:8][n:9][cH:10][c:11]12Participants
3
Sources & evidence
- ORD record
- ord-758abc78960643cb9bd17ea4edd08c1a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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