HCID 68851317, compound → HCID 86600414, compound

HRID 28824Notes

Reaction equation

HRID 28824 reaction equation
[ClH:1].Cl.N[C@H]1CCN([CH2:9][CH:10]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)C1.OC1(C(C2C=CC=C(OC(F)(F)F)C=2)C([N:39]2[CH2:43][CH2:42][C@H:41]([NH:44]C(=O)OC(C)(C)C)[CH2:40]2)=O)CCCCC1>>[ClH:1].[ClH:1].[NH2:44][C@H:41]1[CH2:42][CH2:43][N:39]([CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27][C:22]2([CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][C:18]([F:21])([F:20])[F:19])[CH:12]=2)[CH3:9])[OH:28])[CH2:40]1

Participants

3

Reactant 2

HCID 68851317HCID 68851317, compoundHCID 86600416HCID 86600416, compound

Product 1

HCID 86600414HCID 86600414, compound

Procedure

In an analogous manner to Example 1, step 2, 1-{2-[(3S)-3-aminopyrrolidin-1-yl]-1-[3-(trifluoromethoxy)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl ((3S)-1-{(1-hydroxycyclohexyl)[3-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl)carbamate MS (ESI) m/z 373; HRMS: calcd for C19H27F3N2O2+H, 373.21029; found (ESI, [M+H]+), 373.2106.

Sources & evidence

ORD record
ord-7eac7bfd93894c7d8d57c3b0d3120164
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

Loading…