HCID 68852618, compound → HCID 86600417, compound

HRID 28826Notes

Reaction equation

HRID 28826 reaction equation
[ClH:1].Cl.[CH3:3][N:4]([CH3:29])[C@H:5]1[CH2:9][CH2:8][N:7](CC(C2(O)CCCCC2)C2C=CC=C(C(F)(F)F)C=2)[CH2:6]1.Cl.Cl.N[C@H]1CCN([CH2:38][CH:39]([C:50]2([OH:56])[CH2:55][CH2:54][CH2:53][CH2:52][CH2:51]2)[C:40]2[CH:45]=[CH:44][CH:43]=[C:42]([C:46]([F:49])([F:48])[F:47])[CH:41]=2)C1>>[ClH:1].[ClH:1].[CH3:3][N:4]([CH3:29])[C@H:5]1[CH2:9][CH2:8][N:7]([CH:51]2[CH2:52][CH2:53][CH2:54][CH2:55][C:50]2([CH:39]([C:40]2[CH:45]=[CH:44][CH:43]=[C:42]([C:46]([F:47])([F:49])[F:48])[CH:41]=2)[CH3:38])[OH:56])[CH2:6]1

Participants

3

Reactant 2

HCID 68852618HCID 68852618, compoundHCID 68855271HCID 68855271, compound

Product 1

HCID 86600417HCID 86600417, compound

Procedure

In an analogous manner to Example 36, 1-{2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol dihydrochloride was prepared from, 1-{2-[(3S)-3-aminopyrrolidin-1-yl]-1-[3-(trifluoromethyl)phenyl]ethyl}cyclohexanol (See Example 221). MS (ES) m/z 385.1; HRMS: calcd for C21H31F3N2O+H, 385.24667; found (ESI, [M+H]+), 385.2454.

Sources & evidence

ORD record
ord-aea46af397ab46368daf61e58e879680
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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