1-[1-[4-(Benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol → 1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol Hydrochloride

HRID 28831Notes

Reaction equation

HRID 28831 reaction equation
Cl.C(OC1C([Cl:16])=CC=CC=1C1(OC)CCN(CCC2(O)CCCCC2)CC1)C1C=CC=CC=1.[CH2:34]([O:41][C:42]1[CH:47]=[CH:46][C:45]([CH:48]([C:59]2([OH:65])[CH2:64][CH2:63][CH2:62][CH2:61][CH2:60]2)[C:49]([N:51]2[CH2:56][CH2:55][CH:54]([O:57][CH3:58])[CH2:53][CH2:52]2)=O)=[CH:44][C:43]=1[Cl:66])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[ClH:16].[CH2:34]([O:41][C:42]1[CH:47]=[CH:46][C:45]([CH:48]([C:59]2([OH:65])[CH2:64][CH2:63][CH2:62][CH2:61][CH2:60]2)[CH2:49][N:51]2[CH2:52][CH2:53][CH:54]([O:57][CH3:58])[CH2:55][CH2:56]2)=[CH:44][C:43]=1[Cl:66])[C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1

Participants

3

Reactant 2

HCID 688524421-[1-[4-(Benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanolHCID 86600419HCID 86600419, compound

Product 1

HCID 114887861-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol Hydrochloride

Procedure

In an analogous manner to Example 1, step 2, 1-[1-[4-(benzyloxy-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)ethyl]cyclohexanol hydrochloride was prepared from 1-[1-[4-(benzyloxy)-3-chlorophenyl]-2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexanol HRMS: calcd for C27H36ClNO3+H, 458.24620; found (ESI, [M+H]+), 458.2443.

Sources & evidence

ORD record
ord-7abd0ab0a7dd4cb6b8005d889ed5b4fe
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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