1-[2-(4-Methylpiperazin-1-yl)-1-(1-naphthyl)ethyl]cyclooctanol dihydrochloride → HCID 86600421, compound

HRID 28835Notes

Reaction equation

HRID 28835 reaction equation
[ClH:1].Cl.[CH3:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11](C2(O)CCCCCCC2)[C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[CH2:6][CH2:5]1.Cl.Cl.C1(C([C:51]2([OH:59])[CH2:58][CH2:57][CH2:56][CH2:55][CH2:54][CH2:53][CH2:52]2)CN2CCNCC2)C2C(=CC=CC=2)C=CC=1>>[ClH:1].[ClH:1].[CH3:3][N:4]1[CH2:5][CH2:6][N:7]([CH2:10][CH:11]([CH:52]2[CH2:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH:51]2[OH:59])[C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[CH2:8][CH2:9]1

Participants

3

Reactant 2

HCID 688537221-[2-(4-Methylpiperazin-1-yl)-1-(1-naphthyl)ethyl]cyclooctanol dihydrochlorideHCID 689308101-[1-(1-naphthyl)-2-piperazin-1-ylethyl]cyclooctanol Dihydrochloride

Product 1

HCID 86600421HCID 86600421, compound

Procedure

In an analogous manner to Example 24, 1-[2-(4-methylpiperazin-1-yl)-1-(1-naphthyl)ethyl]cyclooctanol dihydrochloride was prepared from 1-[1-(1-naphthyl)-2-piperazin-1-ylethyl]cyclooctanol dihydrochloride (See Example 269). MS (ESI) m/z 381; HRMS: calcd for C25H36N2O+H, 381.29059; found (ESI, [M+H]+), 381.2893.

Sources & evidence

ORD record
ord-6fede9c1c6df471e86555245bd2d9d8c
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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