HCID 68853738, compound → 1-[2-(4-methylpiperazin-1-yl)-1-(4-phenoxyphenyl)ethyl]cyclohexanol Dihydrochloride

HRID 28837Notes

Reaction equation

HRID 28837 reaction equation
[ClH:1].Cl.CN1CCN(C2CCCCC2(C(C2C=CC(OC3C=CC=CC=3)=CC=2)C)O)CC1.[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([C:39](=O)[CH:40]([C:54]2([OH:60])[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]2)[C:41]2[CH:46]=[CH:45][C:44]([O:47][C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)=[CH:43][CH:42]=2)[CH2:35][CH2:34]1>>[ClH:1].[ClH:1].[CH3:32][N:33]1[CH2:38][CH2:37][N:36]([CH2:39][CH:40]([C:54]2([OH:60])[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]2)[C:41]2[CH:42]=[CH:43][C:44]([O:47][C:48]3[CH:49]=[CH:50][CH:51]=[CH:52][CH:53]=3)=[CH:45][CH:46]=2)[CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 68853738HCID 68853738, compoundHCID 86600333HCID 86600333, compound

Product 1

HCID 688522141-[2-(4-methylpiperazin-1-yl)-1-(4-phenoxyphenyl)ethyl]cyclohexanol Dihydrochloride

Procedure

In an analogous manner to Example 1, step 2 1-[2-(4-methylpiperazin-1-yl)-1-(4-phenoxyphenyl)ethylcyclohexanol dihydrochloride was prepared from 1-[2-(4-methylpiperazin-1-yl)-1-(4-phenoxyphenyl)-2-oxoethy]cyclohexanol. MS(ESI) m/z 395 ([M+H]+). Anal Calcd for C25H34N2O22HCl 0.9H2O: C, 62.08; H, 7.88: N, 5.79. Found: C, 62.26; H, 8.11; N, 5.70.

Sources & evidence

ORD record
ord-e4a595eab1f14d5cac8710d0be215fc7
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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