HCID 68853754, compound → HCID 86600429, compound

HRID 28849Notes

Reaction equation

HRID 28849 reaction equation
[ClH:1].Cl.[NH2:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH:11](C2(O)CCCCC2)[C:12]2[CH:17]=[CH:16][C:15]([O:18]CC3C=CC=CC=3)=[C:14]([Cl:26])[CH:13]=2)[CH2:6][CH2:5]1.[CH2:34]([O:41][C:42]1[CH:47]=[CH:46][C:45](C(C2(O)CCCCC2)C(N2CCC(NC(=O)OC(C)(C)C)CC2)=O)=[CH:44][C:43]=1[Cl:72])[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[ClH:26].[ClH:72].[NH2:3][CH:4]1[CH2:9][CH2:8][N:7]([CH:10]2[CH2:11][CH2:12][CH2:13][CH2:14][C:15]2([CH:16]([C:45]2[CH:46]=[CH:47][C:42]([O:41][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)=[C:43]([Cl:1])[CH:44]=2)[CH3:17])[OH:18])[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 68853754HCID 68853754, compoundHCID 86600431HCID 86600431, compound

Product 1

HCID 86600429HCID 86600429, compound

Procedure

In an analogous manner to Example 1, step 2 {2-(4-aminopiperidin-1-yl)-1-[4-(benzyloxy)-3-chlorophenyl]ethyl}cyclohexanol dihydrochloride was prepared from tert-butyl {1-[[4-(benzyloxy)-3-chlorophenyl](1-hydroxycyclohexyl)acetyl]piperidin-4-yl}carbamate. MS (ESI) m/z 443; HRMS: calcd for C26H35ClN2O2+H+, 443.24598; found (ESI, [M+H]+), 443.2461.

Sources & evidence

ORD record
ord-ce5cbf35b0384b6eaa366fb5d05f5f10
Source dataset
uspto-grants-2008_09
Patent number
US07419980B2

Reaction notes

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