Methanol → 3-Amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione

HRID 288557Notes

Reaction equation

HRID 288557 reaction equation
[CH2:6]([c:10]1[cH:11][cH:12][cH:14][cH:15][cH:16]1)[N:13]([C:7](=[O:8])[O-:9])[CH:17]1[CH2:18][N:19]([S:40](=[O:41])(=[O:42])[c:43]2[c:44]([Cl:50])[cH:45][c:46]([Cl:49])[cH:47][cH:48]2)[CH:20]2[N:21]([C:22]1=[O:23])[CH:24]([CH2:32][c:33]1[cH:34][cH:35][c:36]([Cl:39])[cH:37][cH:38]1)[C:25](=[O:31])[N:26]([CH:28]([CH3:29])[CH3:30])[CH2:27]2.[CH3:1][Si:2]([I:3])([CH3:4])[CH3:5].[CH3:51][OH:52].[CH3:53][C:54]#[N:55]>>[NH2:13][CH:17]1[CH2:18][N:19]([S:40](=[O:41])(=[O:42])[c:43]2[c:44]([Cl:50])[cH:45][c:46]([Cl:49])[cH:47][cH:48]2)[CH:20]2[N:21]([C:22]1=[O:23])[CH:24]([CH2:32][c:33]1[cH:34][cH:35][c:36]([Cl:39])[cH:37][cH:38]1)[C:25](=[O:31])[N:26]([CH:28]([CH3:29])[CH3:30])[CH2:27]2

Participants

5

Reactant 4

HCID 887MethanolHCID 6342AcetonitrileHCID 85247Trimethylsilyl iodideHCID 178456172HCID 178456172, compound

Product 1

HCID 591342523-Amino-6-(4-chlorobenzyl)-1-(2,4-dichlorobenzenesulfonyl)-8-isopropylhexahydropyrazino[1,2-a]pyrimidine-4,7-dione

Sources & evidence

ORD record
ord-1ed2ab8644da4f95922fd4cb37dde904
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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