Methanol → 4-[5-Amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-yl]-phenol

HRID 288558Notes

Reaction equation

HRID 288558 reaction equation
[B:26]([Br:27])([Br:28])[Br:29].[CH3:30][OH:31].[Cl:34][CH2:35][Cl:36].[F:1][c:2]1[c:3](-[c:12]2[c:13]([NH2:25])[n:14](-[c:17]3[cH:18][cH:19][c:20]([O:23][CH3:24])[cH:21][cH:22]3)[n:15][n:16]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[Na+:33].[OH-:32].[OH2:37]>>[F:1][c:2]1[c:3](-[c:12]2[c:13]([NH2:25])[n:14](-[c:17]3[cH:18][cH:19][c:20]([OH:23])[cH:21][cH:22]3)[n:15][n:16]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1

Participants

8

Reactant 7

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 252159065-(2-Fluoro-4-trifluoromethyl-phenyl)-3-(4-methoxy-phenyl)-3H-[1,2,3]triazol-4-ylamine

Product 1

HCID 252159074-[5-Amino-4-(2-fluoro-4-trifluoromethyl-phenyl)-[1,2,3]triazol-1-yl]-phenol

Sources & evidence

ORD record
ord-bb2083f050c940bda6cb57291c232424
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…