Ethyl isocyanate → HCID 24815964, compound

HRID 28895Notes

Reaction equation

[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[C:19]([CH2:23][N:24]5[CH2:28]CC[CH2:25]5)[CH:18]=4)=[CH:16][C:9]=23)[C:5]([C:29]2[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=2)=[N:4]1)[CH3:2].[CH2:36]([N:38]=[C:39]=[O:40])[CH3:37]>>[CH3:28][N:24]([CH2:23][C:19]1[CH:18]=[C:17]([C:15]2[NH:14][C:10]3=[N:11][CH:12]=[CH:13][C:8]([C:6]4[C:5]([C:29]5[CH:30]=[CH:31][C:32]([NH:35][C:39]([NH:38][CH2:36][CH3:37])=[O:40])=[CH:33][CH:34]=5)=[N:4][N:3]([CH2:1][CH3:2])[CH:7]=4)=[C:9]3[CH:16]=2)[CH:22]=[CH:21][CH:20]=1)[CH3:25]

Participants

Reactant 2

HCID 8022Ethyl isocyanate

HCID 68995199HCID 68995199, compound

Product 1

HCID 24815964HCID 24815964, compound

Procedure

Following the procedure described in Example 48 using [4-(1-ethyl-4-{2-[3-(1-pyrrolidinylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-3-yl)phenyl]amine and ethyl isocyanate provided the title compound. ESMS [M+H]+: 534.5

Sources & evidence

ORD record: ord-5de3f38589f94e24baa8b951ffbf3049
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07419988B2

Reaction notes

Loading…