HRID28896

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCn1cc(-c2ccnc3[nH]c(-c4ccc5c(c4)CN(C(C)=O)CC5)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1

HCID58980031

未命名化合物

PRODUCTS

生成物

结构：CCn1cc(-c2ccnc3[nH]c(-c4ccc5c(c4)CNCC5)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1

HCID58980067

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Following the procedure described in Example 11 using N′-(4-{4-[2-(2-acetyl-1,2,3,4-tetrahydro-7-isoquinolinyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea in ethanol at 100° C. provided the title compound. ESMS [M+H]+: 507.4

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0d2120ccaa754189a2c19197a37df264
来源数据集: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07419988B2
来源说明: uspto-grants-2008_09

反应 SMILES

C([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][C:8]([C:14]3[NH:41][C:17]4=[N:18][CH:19]=[CH:20][C:21]([C:22]5[C:23]([C:29]6[CH:34]=[CH:33][C:32]([NH:35][C:36](=[O:40])[N:37]([CH3:39])[CH3:38])=[CH:31][CH:30]=6)=[N:24][N:25]([CH2:27][CH3:28])[CH:26]=5)=[C:16]4[CH:15]=3)=[CH:9][CH:10]=2)[CH2:5]1)(=O)C>C(O)C>[CH2:27]([N:25]1[CH:26]=[C:22]([C:21]2[CH:20]=[CH:19][N:18]=[C:17]3[NH:41][C:14]([C:8]4[CH:7]=[C:6]5[C:11]([CH2:12][CH2:13][NH:4][CH2:5]5)=[CH:10][CH:9]=4)=[CH:15][C:16]=23)[C:23]([C:29]2[CH:34]=[CH:33][C:32]([NH:35][C:36](=[O:40])[N:37]([CH3:39])[CH3:38])=[CH:31][CH:30]=2)=[N:24]1)[CH3:28]