8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 8-{4-[2-(3-Benzyloxy-propoxy)-6-fluoro-phenylamino]-5-chloro pyrimidin-2-ylamino}-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 288979Notes

Reaction equation

HRID 288979 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]([NH:20][c:21]2[n:22][c:23]([Cl:28])[n:24][cH:25][c:26]2[Cl:27])[c:15]([F:19])[cH:16][cH:17][cH:18]1.[NH2:29][c:30]1[cH:31][cH:32][c:33]2[c:34]([cH:41]1)[NH:35][C:36](=[O:40])[CH2:37][CH2:38][CH2:39]2>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][CH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]([NH:20][c:21]2[n:22][c:23]([NH:29][c:30]3[cH:31][cH:32][c:33]4[c:34]([cH:41]3)[NH:35][C:36](=[O:40])[CH2:37][CH2:38][CH2:39]4)[n:24][cH:25][c:26]2[Cl:27])[c:15]([F:19])[cH:16][cH:17][cH:18]1

Participants

3

Reactant 2

HCID 46151688-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-oneHCID 86634001[2-(3-Benzyloxy-propoxy)-6-fluoro-phenyl]-(2,5-dichloro-pyrimidin-4-yl)-amine

Product 1

HCID 668306418-{4-[2-(3-Benzyloxy-propoxy)-6-fluoro-phenylamino]-5-chloro pyrimidin-2-ylamino}-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-db24f226f20c4a899caf1160f8338ec6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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