HCID 68998288, compound → HCID 69000369, compound

HRID 28971Notes

Reaction equation

Br[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8]([S:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)(=[O:26])=[O:25])[C:9]([C:11]3[CH:16]=[CH:15][C:14]([CH2:17][N:18]4[CH2:23][CH2:22][O:21][CH2:20][CH2:19]4)=[CH:13][CH:12]=3)=[CH:10][C:3]=12.[N+:33]([C:36]1[CH:41]=[CH:40][C:39]([C:42]2[C:46](B3OC(C)(C)C(C)(C)O3)=[CH:45][N:44]([CH2:56][CH2:57][OH:58])[N:43]=2)=[CH:38][CH:37]=1)([O-:35])=[O:34]>>[N+:33]([C:36]1[CH:37]=[CH:38][C:39]([C:42]2[C:46]([C:2]3[CH:7]=[CH:6][N:5]=[C:4]4[N:8]([S:24]([C:27]5[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=5)(=[O:26])=[O:25])[C:9]([C:11]5[CH:12]=[CH:13][C:14]([CH2:17][N:18]6[CH2:19][CH2:20][O:21][CH2:22][CH2:23]6)=[CH:15][CH:16]=5)=[CH:10][C:3]=34)=[CH:45][N:44]([CH2:56][CH2:57][OH:58])[N:43]=2)=[CH:40][CH:41]=1)([O-:35])=[O:34]

Participants

Reactant 2

HCID 68998288HCID 68998288, compound

HCID 68999617HCID 68999617, compound

Product 1

HCID 69000369HCID 69000369, compound

Procedure

Following the procedure for Intermediate 100 using 4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine and 3-(4-nitrophenyl)-1-(2-hydroxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole provided the title compound. ESMS [M+H]+: 665.2

Sources & evidence

ORD record: ord-72b8e9cab1dd465a892510c7ed9ab8ba
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07419988B2

Reaction notes

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