2-(Ethylamino)ethanol → 2-(ethyl {[4-[1-ethyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]methyl}amino)ethanol

HRID 28979Notes

Reaction equation

HRID 28979 reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[N:14]([S:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)(=[O:21])=[O:20])[C:15]([CH:17]=O)=[CH:16][C:9]=23)[C:5]([C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=2)=[N:4]1)[CH3:2].[CH2:37]([NH:39][CH2:40][CH2:41][OH:42])[CH3:38]>>[CH2:37]([N:39]([CH2:17][C:15]1[N:14]([S:19]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)(=[O:20])=[O:21])[C:10]2=[N:11][CH:12]=[CH:13][C:8]([C:6]3[C:5]([C:28]4[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=4)=[N:4][N:3]([CH2:1][CH3:2])[CH:7]=3)=[C:9]2[CH:16]=1)[CH2:40][CH2:41][OH:42])[CH3:38]

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 866133274-[1-ethyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde

Product 1

HCID 690006272-(ethyl {[4-[1-ethyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]methyl}amino)ethanol

Procedure

Following the procedure described in Intermediate 101 using 4-[1-ethyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde and 2-(ethylamino)ethanol provided the title compound as a yellow solid. ESMS [M+H]+: 651.4.

Sources & evidence

ORD record
ord-4fbbab026b8e4b5c98cf0c01fcc10e72
Source dataset
uspto-grants-2008_09
Patent number
US07419988B2

Reaction notes

Loading…