1-(2-Hydroxyethyl)piperazine → 2-[4-({4-[4-[1-methyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}methyl)-1-piperazinyl]ethanol

HRID 28992Notes

Reaction equation

HRID 28992 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]3[N:13]([S:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)(=[O:26])=[O:25])[C:14]([C:16]4[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=4)=[CH:15][C:8]=23)[C:4]([C:33]2[CH:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=2)=[N:3]1.[N:42]1([CH2:48][CH2:49][OH:50])[CH2:47][CH2:46][NH:45][CH2:44][CH2:43]1>>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]3[N:13]([S:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)(=[O:25])=[O:26])[C:14]([C:16]4[CH:17]=[CH:18][C:19]([CH2:20][N:45]5[CH2:46][CH2:47][N:42]([CH2:48][CH2:49][OH:50])[CH2:43][CH2:44]5)=[CH:22][CH:23]=4)=[CH:15][C:8]=23)[C:4]([C:33]2[CH:34]=[CH:35][C:36]([N+:39]([O-:41])=[O:40])=[CH:37][CH:38]=2)=[N:3]1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 86613330HCID 86613330, compound

Product 1

HCID 690039682-[4-({4-[4-[1-methyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]phenyl}methyl)-1-piperazinyl]ethanol

Procedure

Following the procedure described for Intermediate 101 using 4-[4-[1-methyl-3-(4-nitrophenyl)-1H-pyrazol-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]benzaldehyde and 2-(1-piperazinyl)ethanol provided the title compound. ESMS [M+H]+: 678.4.

Sources & evidence

ORD record
ord-fafa265a53654b76b690247ad1347488
Source dataset
uspto-grants-2008_09
Patent number
US07419988B2

Reaction notes

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