Acetic Acid → 1'-({6-Chloro-1-[(1-methylpyrrolidin-3-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine]

HRID 290184Notes

Reaction equation

HRID 290184 reaction equation
[C:33]([OH:34])(=[O:35])[CH3:36].[CH3:37][OH:38].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:17](=[O:18])[N:19]3[CH2:20][CH2:21][C:22]4([O:23][CH2:24][c:25]5[c:26]4[cH:27][cH:28][cH:29][cH:30]5)[CH2:31][CH2:32]3)[cH:7][n:8]([CH2:11][CH:12]3[CH2:13][NH:14][CH2:15][CH2:16]3)[c:9]2[cH:10]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:17](=[O:18])[N:19]3[CH2:20][CH2:21][C:22]4([O:23][CH2:24][c:25]5[c:26]4[cH:27][cH:28][cH:29][cH:30]5)[CH2:31][CH2:32]3)[cH:7][n:8]([CH2:11][CH:12]3[CH2:13][N:14]([CH3:33])[CH2:15][CH2:16]3)[c:9]2[cH:10]1

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 887MethanolHCID 59657701HCID 59657701, compound

Product 1

HCID 596575131'-({6-Chloro-1-[(1-methylpyrrolidin-3-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine]

Sources & evidence

ORD record
ord-8ee3f8684639494c82dfe5d0bbd4e6f0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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