反应详情

200 mg (0.46 mmol) of the compound obtained in Example 1 was dissolved in 10 ml of methanol, to which 100 mg of Raney-Ni was added. Reaction was continued for 14 hours at room temperature with 3 atmospheric pressure of hydrogen gas. The reaction solution was filtered to eliminate Ni, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1), to give 177 mg (yield: 96%) of the target compound.

1. additionwas added
2. customReaction
3. filtrationThe reaction solution was filtered
4. concentrationconcentrated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)