HRID2908

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14797

Potassium hydroxide

HKO

结构：CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)OC)c(=O)n2Cc1ccccc1OC

HCID9913328

未命名化合物

结构：CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC

HCID10288713

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc2nc(OCc3ccccc3OC)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c2c1

HCID22445866

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

A solution of 0.5 g of methyl 4-(1,3-benzodioxol-5-yl)-1,2-dihydro-6-ethoxy-1-(2-methoxybenzyl)-2-oxoquinoline-3-carboxylate and 6 ml of 5N KOH in 10 ml of methanol is boiled under reflux for 2 hours. The usual working up results in 4-(1,3-benzodioxol-5-yl)-1,2-dihydro-6-ethoxy-1-(2-methoxybenzyl)-2-oxoquinoline-3-carboxylic acid, m.p. 225°-226°. Analogously, the O-alkylation product 4-(1, 3-benzodioxol-5-yl)-6-ethoxy-2-(2-methoxybenzyloxy)quinoline-3-carboxylic acid is obtained from methyl 4-(1,3-benzodioxol-5-yl)-6-ethoxy-2-(2-methoxybenzyloxy) quinoline-3-carboxylate.

WORKUP

后处理

temperatureunder reflux for 2 hours

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3aafaa9bc09e4d7e91b49eec25c1596b
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05731321
来源说明: uspto-grants-1998_03

反应 SMILES

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([O:20][CH2:21][CH3:22])[CH:18]=4)[N:13](CC4C=CC=CC=4OC)[C:12](=[O:32])[C:11]=3[C:33]([O:35]C)=[O:34])=[CH:9][C:4]=2[O:3][CH2:2]1.[OH-].[K+].O1C2C=CC(C3C4C(=CC=C(OCC)C=4)N([CH2:61][C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][C:63]=4[O:68][CH3:69])C(=O)C=3C(O)=O)=CC=2OC1>CO>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([O:20][CH2:21][CH3:22])[CH:18]=4)[N:13]=[C:12]([O:32][CH2:61][C:62]4[CH:67]=[CH:66][CH:65]=[CH:64][C:63]=4[O:68][CH3:69])[C:11]=3[C:33]([OH:35])=[O:34])=[CH:9][C:4]=2[O:3][CH2:2]1