1,1-Dichloroethane → 1-cyclohexyl-3-[7-(2,2-dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea

HRID 291185Notes

Reaction equation

HRID 291185 reaction equation
[Cl:34][CH:35]([Cl:36])[CH3:37].[NH2:1][c:2]1[n:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[cH:9][c:10]2[C:11]([C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16].[O:25]=[C:26]=[N:27][CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1>>[NH:1]([c:2]1[n:3][c:4]2[c:5]([n:6][cH:7]1)[n:8]([CH2:17][O:18][CH2:19][CH2:20][Si:21]([CH3:22])([CH3:23])[CH3:24])[cH:9][c:10]2[C:11]([C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16])[C:26](=[O:25])[NH:27][CH:28]1[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]1

Participants

4

Reactant 3

HCID 63651,1-DichloroethaneHCID 18502Cyclohexyl isocyanateHCID 578310481-[2-amino-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-2,2-dimethyl-propan-1-one

Product 1

HCID 578310441-cyclohexyl-3-[7-(2,2-dimethyl-propionyl)-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-urea

Sources & evidence

ORD record
ord-71fba43607704fec9b0db4763d04267c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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