Dimethylformamide → N-[2,3,6-Trimethyl-4-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]phenyl]formamide

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	N-(4-hydroxy-2,3,6-trimethylphenyl)formamide	HCID 21961295	—
반응물	1-(3-Chloro-2-methyl-1-propenyl)-4-methylbenzene	HCID 69150787	—
용매	Water	HCID 962	—
용매	Toluene	HCID 1140	—
생성물	N-[2,3,6-Trimethyl-4-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]phenyl]formamide	HCID 73856749	78.9%

반응 조건

온도	50 °C

반응 단계

To a mixture of N-(4-hydroxy-2,3,6-trimethylphenyl)formamide (660.4 g), potassium carbonate (1019 g) and dimethylformamide (3302 ml) was added a solution of 1-(3-chloro-2-methyl-1-propenyl)-4-methylbenzene (755 g) in toluene (675 ml), and the mixture was stirred at 50° C. for 14 hr. Water (5944 ml) was then added thereto and the mixture was stirred at 30° C. for 1 hr. The precipitated crystals were collected by filtration and washed with water and isopropylether to give the title compound (940 g, yield 74.5%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07420070B2
출처 데이터셋	uspto-grants-2008_09
ORD ID	ord-63c2819b8d404cafaa4e24dfc1980e78
출처 메모	uspto-grants-2008_09