Bicarbonate Ion → 1,1-dimethylethyl 5-(4-aminofuro[3,2-c]pyridin-3-yl)-4-fluoro-2,3-dihydro-1H-indole-1-carboxylate

HRID 291673Notes

Reaction equation

HRID 291673 reaction equation
[Br:1][c:2]1[cH:3][o:4][c:5]2[c:6]1[c:7]([NH2:11])[n:8][cH:9][cH:10]2.[C:38](=[O:39])([OH:40])[O-:41].[CH2:43]1[O:44][CH2:45][CH2:46][O:47][CH2:48]1.[F:12][c:13]1[c:14]2[c:18]([cH:19][cH:20][c:21]1[B:22]1[O:23][C:24]([CH3:25])([CH3:26])[C:27]([CH3:28])([CH3:29])[O:30]1)[N:17]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:16][CH2:15]2.[Na+:42]>>[c:2]1(-[c:21]2[c:13]([F:12])[c:14]3[c:18]([cH:19][cH:20]2)[N:17]([C:31](=[O:32])[O:33][C:34]([CH3:35])([CH3:36])[CH3:37])[CH2:16][CH2:15]3)[cH:3][o:4][c:5]2[c:6]1[c:7]([NH2:11])[n:8][cH:9][cH:10]2

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 312751,4-DioxaneHCID 184507953-Bromofuro[3,2-c]pyridin-4-amineHCID 66823308Tert-butyl 4-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline-1-carboxylate

Product 1

HCID 668239041,1-dimethylethyl 5-(4-aminofuro[3,2-c]pyridin-3-yl)-4-fluoro-2,3-dihydro-1H-indole-1-carboxylate

Sources & evidence

ORD record
ord-e01fa91b2d4448dea90c751e32918b39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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