Sodium periodate → HCID 68849826, compound

Participants

Reaction Steps

To a stirred solution of 2-(3,5-dichlorophenoxy)-N-(6-methyl-1-methylthio-hept-4-yn-6-yl) butyramide (0.21 g) in ethanol (2.5 ml) at ambient temperature was added dropwise a solution of sodium periodate (0.13 g) in water (2.5 ml). The mixture was stirred for 2.5 hours, stored for 18 hours then evaporated under reduced pressure. The residue was extracted with dichloromethane and the organic phase filtered then evaporated under reduced pressure to give the required product as a colourless oil, 0.18 g, 1H NMR (CDCl3) δ: 0.98-1.02(3H, t); 1.56(3H, s); 1.58(3H, s); 1.92-2.00(4H, m); 2.34-2.42((2H, m); 2.62(3H, s); 2.76-2.84(1H, m); 2.90-2.96(1H, m); 4.34-4.38(1H, m); 6.26(1H, s); 6.82(2H, s); 7.02(1H, s).

Provenance & Evidence