反应详情

N-({4′-[(1-benzofuran-2-ylcarbonyl)amino]-1,1′-biphenyl-4-yl}sulfonyl)glycine t-butyl ester (75 mg) was dissolved in a 95% solution of TFA in methylene chloride (5 mL). The solution was stirred at room temperature for 4 h and the solvent was removed under vacuum. The crude product was triturated with hexane/ethyl acetate (95:5) three times. The product was lyophilized with benzene to give 56 mg of N-({4′-[(1-benzofuran-2-ylcarbonyl)amino]-1,1′-biphenyl-4-yl}sulfonyl)glycine. LCMS MH+ (m/z) 451. 1H NMR (300 MHz, DMSO-d6): δ 10.54 ppm (s, 1H), 7.95-7.54 ppm (m, 11H), 7.34 ppm (dd, 1H, J1=7.5 Hz, J2=7.5 Hz), 7.20 ppm (dd, 1H, J1=7.5 Hz, J2=7.5 Hz), 3.42 ppm (d, 2H J=6.3 Hz).

1. customthe solvent was removed under vacuum
2. customThe crude product was triturated with hexane/ethyl acetate (95:5) three times